This study identifies novel genetic signals associated with severe obesity through GWAS and shows strong genetic overlap with BMI, highlighting shared comorbidities and lifestyle interactions.

PLoS Genetics · Sep 12, 2025Peer-reviewedGenetic & Genomic Medicine

Genome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

Mélanie Guirette, Jessie Jie Lan, Nicola Mary McKeown, Michael R. Brown, Han Chen, Paul S. de Vries, Hyunju Kim, Casey M. Rebholz, Alanna C. Morrison, Traci M. Bartz, Amanda M. Fretts, Xiuqing Guo, Rozenn N. Lemaître, Ching‐Ti Liu, Raymond Noordam, , On behalf of the CHARGE Gene-Lifestyle Interactions Working Group

The paper identifies novel genetic loci associated with systolic blood pressure that interact with the DASH diet score through genome-wide interaction analysis.

Hypertension · Jan 16, 2024Peer-reviewedGenetic & Genomic Medicine

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

Iain Mathieson, Felix R. Day, Nicola Barban, Felix C. Tropf, David M. Brazel, Diana van Heemst, Ahmad Vaez, Natalie R. van Zuydam, Bárbara Domingues Bitarello, Eugene J. Gardner, Evelina Tamerlanov Akimova, Ajuna Azad, Sven Bergmann, Lawrence F. Bielak, Dorret Irene Boomsma, , Vallari Shukla

This study identifies 43 genomic loci associated with reproductive success in 785,604 individuals, showing ongoing natural selection at the FADS locus.

Nature Human Behaviour · Mar 2, 2023Peer-reviewedGenetics

Genome-wide characterization of circulating metabolic biomarkers reveals substantial pleiotropy and novel disease pathways

Minna K. Karjalainen, Savita Karthikeyan, Clare Oliver‐Williams, Eeva Sliz, Elias Allara, Praveen Surendran, Weihua Zhang, Pekka Jousilahti, Kati Kristiansson, Veikko V Salomaa, Matt Goodwin, David A. Hughes, Michael Boehnke, Lilian Fernandes Silva, Xianyong Yin, , Johannes Kettunen

This study identifies 400+ genetic loci associated with circulating metabolic traits and highlights pleiotropy and novel disease pathways.

medRxiv · Oct 20, 2022 · PreprintGenetic & Genomic Medicine

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

Natasha Hui Jin Ng, Sara M. Willems, Juan Fernandez, Rebecca S. Fine, Eleanor Wheeler, Jennifer Wessel, Hidetoshi Kitajima, Gaëlle Marenne, Jana K. Rundle, Xueling Sim, Hanieh Yeghootkar, Nicola L. Beer, Anne Raimondo, Andrei I. Tarasov, Soren K. Thomsen, , Abbas Dehghan

The paper identifies genetic variants and transcripts associated with glycemic traits by analyzing exome-array data from 144,600 individuals, highlighting tissue-specific roles in glucose regulation.

bioRxiv · Oct 3, 2019 · PreprintGenetics

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

Anne E. Justice, Tugce Karaderi, Heather M. Highland, Kristin L. Young, Mariaelisa Graff, Yingchang Lu, Valérie Turcot, Paul Livermore Auer, Rebecca S. Fine, Xiuqing Guo, Claudia Schurmann, Adelheid M. Lempradl, Eirini Marouli, Anubha Mahajan, Thomas W. Winkler, , Andrew Tym Hattersley

This study identifies 15 common and 9 low-frequency protein-coding variants associated with body fat distribution, implicating novel genes related to lipid homeostasis and type 2 diabetes.

Nature Genetics · Feb 18, 2019Peer-reviewedGenetics

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

Annah B. Wyss, Tamar Sofer, Mi Kyeong Lee, Natalie Terzikhan, Jennifer N. Nguyen, Lies Lahousse, Jeanne C. Latourelle, Albert V. Smith, Traci M. Bartz, Mary Furlan Feitosa, Wei Dong Gao, Tarunveer S. Ahluwalia, Wenbo Tang, Christopher J. Oldmeadow, Qing Duan, , Josée Dupuis

This study identifies over 50 new genetic loci associated with pulmonary function through a multiethnic meta-analysis of 90,715 individuals.

Nature Communications · Jul 24, 2018Peer-reviewedGenetics

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove, Traci M. Bartz, Ma’en Obeidat, Michael A. Province, Wei Dong Gao, Beenish Qaiser, David John Porteous, Patricia A. Cassano, Tarunveer S. Ahluwalia, Niels Grarup, Jin Li, , Sven Gläser

Wellcome Open Research · Jan 12, 2018Peer-reviewedGenetics

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

Louise V. Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J. van der Most, Abdullah Mesut Erzurumluoglu, Paul F. O’Reilly, Claudia P. Cabrera, Helen R. Warren, Lynda M. Rose, Germaine C. Verwoert, Jouke‐Jan Hottenga, Rona J. Strawbridge, Tõnu Esko, Dan E. Arking, , Tamara B. Harris

This study identifies 6 new blood pressure loci and 48 genes involved in BP regulation using GWAS and gene expression data from blood and kidney tissues.

Hypertension · Jul 24, 2017Peer-reviewedGenomics