Heterotypic Assembly Mechanism Regulates CHIP E3 Ligase Activity
Aniruddha Das, Pankaj Singh Thapa, Ulises Santiago, Nilesh Shanmugam, Katarzyna Banasiak, Katarzyna Dąbrowska, Hendrik Nolte, Natalia A. Szulc, Rose Muthoni Gathungu, Dominik Cysewski, Marcus Krüger, Michał Dadlez, Marcin Nowotny, Carlos Jaime Camacho, Thorsten Hoppe, Wojciech Pokrzywa
The paper investigates how the CHN-1/UFD-2 complex enhances ubiquitin chain formation through dimerization and chaperone-mediated regulation of substrate ubiquitylation.
The EMBO Journal · Jun 28, 2022Peer-reviewedMolecular Biology