Carlos Jaime Camacho

The paper investigates genetic and physical interactions of DSB factors in C. elegans, revealing HIM-5's role in X-chromosome-specific crossovers and its dependency on DSB-1.

The paper introduces consensus signatures to identify conserved gene regulation principles across cell types and finds ORC1 down-regulation by CDK4/6 inhibitors disrupts a feedback loop for E2F2-driven proliferation.

This study identifies PDA1 as an SH3-binding allosteric modulator that stabilizes Hck conformation, potentially enhancing combination therapy with ATP-site inhibitors.

The paper investigates how the CHN-1/UFD-2 complex enhances ubiquitin chain formation through dimerization and chaperone-mediated regulation of substrate ubiquitylation.

This study identifies MAP2 phosphorylation changes in schizophrenia, linking them to neuronal structure and synaptic function impairments through phosphoproteomics and transgenic mouse models.

The paper develops a pipeline to predict protein targets for drug-like compounds using transcriptomics and machine learning, achieving 26% top-10 accuracy on FDA-approved drugs.