Author

Anna Steinzeig

University of HelsinkiORCID 0000-0001-7209-2811Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Eero ĊastréniD· 4 shared Frederike WinkeliD· 3 shared Caroline BiojoneiD· 2 shared Cecilia CannarozzoiD· 2 shared Hanna AntilaiD· 2 shared Juzoh UmemoriiD· 2 shared Plinio Cabrera CasarottoiD· 2 shared Sari E. LauriiD· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersNeuroscience

Eero ĊastrénORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Plinio Cabrera Casarotto, Mykhailo Girych, Senem Merve Fred, Vera D. Kovaleva, Rafael Moliner, Giray Enkavi, Caroline Biojone, Cecilia Cannarozzo, Madhusmita Priyadarshini Sahu, Katja Kaurinkoski, Cecilia Anna Brunello, Anna Steinzeig, Frederike Winkel, Sudarshan S. Patil, Stefan Vestring, , Eero Ċastrén

This study identifies a direct binding of antidepressants to TRKB receptors, revealing a mechanism linking molecular interactions to antidepressant effects.

Cell · Feb 18, 2021Peer-reviewedNeuroscience

Chondroitinase and antidepressants promote plasticity by releasing TRKB from dephosphorylating control of PTPσ in parvalbumin neurons

Angelina Lesnikova, Plinio Cabrera Casarotto, Senem Merve Fred, Mikko Voipio, Frederike Winkel, Anna Steinzeig, Hanna Antila, Juzoh Umemori, Caroline Biojone, Eero Ċastrén

This study shows that chondroitinase and antidepressants promote plasticity in the adult visual cortex by enhancing TRKB signaling in parvalbumin neurons through inhibition of PTPσ.

Journal of Neuroscience · Dec 8, 2020Peer-reviewedNeuroscience

Optical TrkB activation in Parvalbumin interneurons regulates intrinsic states to orchestrate cortical plasticity

Frederike Winkel, Mathias Benjamin Voigt, Giuliano Didio, Salomé Matéo, Elias Jetsonen, Maria Llach Pou, Anna Steinzeig, Maria Ryazantseva, Juliana Harkki, Jonas Englund, Stanislav Khirug, Claudio Rivera, Satu Palva, Tomi Taira, Sari E. Lauri, , Eero Ċastrén

The paper shows that optogenetic activation of TrkB receptors in PV interneurons increases cortical plasticity by altering neuronal excitability and gene expression.

bioRxiv · Apr 27, 2020 · PreprintNeuroscience

Temporal patterns of fluoxetine-induced plasticity in the mouse visual cortex

Anna Steinzeig, Cecilia Cannarozzo, Eero Ċastrén

This study shows that fluoxetine can extend ocular dominance plasticity in adult mice beyond the natural critical period, but the effect stops when the drug is discontinued.

bioRxiv · Dec 4, 2018 · PreprintNeuroscience