Author

Patrice Mascalchi

Centre National de la Recherche ScientifiqueORCID 0000-0002-5794-2010Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Research Focus:imputation· 1 Research Focus:protein design· 1

Frequent Co-Authors

Aaron T. L. LuniD· 1 shared Alexis R. BarriD· 1 shared Benjamin CompansiD· 1 shared Cameron D. MackerethiD· 1 shared Camille Genuer· 1 shared Charlotte RimbaultiD· 1 shared Chris BakaliD· 1 shared Christel PoujoliD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenomics

Aaron T. L. LunORCID

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2 papers

Recent·Most cited

Engineering paralog-specific PSD-95 synthetic binders as potent and minimally invasive imaging probes

Charlotte Rimbault, Christelle Breillat, Benjamin Compans, Estelle Toulmé, Filipe Nunes Vicente, Mónica Fernández‐Monreal, Patrice Mascalchi, Camille Genuer, Virginia Puente‐Muñoz, Isabel Gauthereau, Eric Hosy, Stéphane Claverol, Grégory Giannone, Ingrid Chamma, Cameron D. Mackereth, , Matthieu Sainlos

The paper develops synthetic binders specific to PSD-95 for imaging endogenous proteins with minimal impact on function and compatibility with super-resolution techniques.

eLife · Jan 3, 2024Peer-reviewedNeuroscience

Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis

Lovorka Stojic, Aaron T. L. Lun, Jasmin Mangei, Patrice Mascalchi, Valentina Quarantotti, Alexis R. Barr, Chris Bakal, John C. Marioni, Fanni V. Gergely, Duncan T. Odom

This study compares the off-target effects of RNAi, antisense oligonucleotides, and CRISPRi in transcriptomic analyses, showing that all methods have non-negligible off-target effects and recommend using multiple LOF methods for functional validation.

Nucleic Acids Research · May 9, 2018Peer-reviewedGenomics