Evangelia K. Papachristou

This paper shows that IL-1-activated cancer-associated fibroblasts (iCAFs) promote STAT1-driven transcriptional reprogramming in pancreatic tumour cells, leading to chemoresistance and identifying STAT1 as a therapeutic target.

The paper compares ASCL1 interactomes in neuroblastoma cell lines to identify CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified cells.

This study identifies MOZ and HBO1 as molecular dependencies in NUP98-rearranged AML, showing their inhibition reduces leukemic burden and synergizes with Menin inhibitors.

The paper investigates the role of GLP methyltransferase in oocyte development using multi-omics analysis and mouse models, finding that GLP contributes to transcriptional repression and is critical for oogenesis.

The paper examines how MEK and GSK3 inhibition affects the methylome and transcriptome of mouse embryonic stem cells, revealing distinct epigenetic and transcriptional changes.