Author

Silvia Jimeno-González

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-6223-9573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Amador Romero-FrancoiD· 1 shared Andrés AguileraiD· 1 shared Andrés Herrero-RuíziD· 1 shared Angela GalloiD· 1 shared Carlos SuñéiD· 1 shared Domenico Alessandro SilvestrisiD· 1 shared Esther Lara· 1 shared Felipe Cortés‐LedesmaiD· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperGenetics

Amador Romero-FrancoORCID

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3 papers

Recent·Most cited

ADAR2-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair

Sonia Jimeno, Rosario Prados‐Carvajal, María Jesús Fernández-Ávila, Sonia de Regules Silva, Domenico Alessandro Silvestris, Martín Endara-Coll, Guillermo Rodríguez‐Real, Judit Domingo‐Prim, Fernando Mejías-Navarro, Amador Romero-Franco, Silvia Jimeno-González, Sonia I. Barroso, Valeriana Cesarini, Andrés Aguilera, Angela Gallo, , Pablo Huertas

The paper shows that ADAR2-mediated RNA editing of DNA:RNA hybrids is essential for DNA double strand break repair by facilitating DNA end resection.

Nature Communications · Sep 17, 2021Peer-reviewedGenetics

Human Prefoldin Modulates Co-transcriptional Pre-mRNA Splicing

Laura Payán-Bravo, Sara Fontalva, Xenia Peñate, Ildefonso Cases, Jose Antonio Guerrero-Martinez, Yerma Pareja Sanchez, Yosu Odriozola‐Gil, Esther Lara, Silvia Jimeno-González, Carlos Suñé, Mari Cruz Muñoz-Centeno, José C. Reyes, Sebastián Chávez

This study shows that human prefoldin affects co-transcriptional pre-mRNA splicing by modulating RNA polymerase II phosphorylation and splicing factor recruitment.

Nucleic Acids Research · May 7, 2021Peer-reviewedMolecular Biology

Control of RNA polymerase II promoter-proximal pausing by DNA supercoiling

Andrés Herrero-Ruíz, Pedro Manuel Martínez‐García, J. Terrón-Bautista, Jeffrey Alan Lieberman, Silvia Jimeno-González, Felipe Cortés‐Ledesma

The paper shows that topoisomerase IIa removes negative DNA supercoiling at promoters, repressing transcription by enforcing Pol II pausing, and reveals this as a novel regulatory mechanism for gene expression.

bioRxiv · May 12, 2020 · PreprintMolecular Biology