Valerie A. C. M. Koeken

Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia

The paper investigates immune correlates of early Mtb clearance in TB household contacts, finding that BCG vaccination is linked to enhanced innate immune responses rather than adaptive immunity.

Epigenetic Reprogramming Mediates Monocyte and Heterologous T Cell-derived Cytokine Responses after BCG Vaccination

This study investigates how DNA methylation changes after BCG vaccination influence cytokine responses and identifies epigenetic pathways mediating genetic effects on immune responses.

Host genetic variants regulates CCR5 expression on immune cells: a study in people living with HIV and healthy controls

This study identifies genetic variants influencing CCR5 expression on immune cells in HIV-positive and healthy individuals, showing cell-specific regulation and effects on inflammatory mediators.

The genetic risk for COVID-19 severity is associated with defective innate immune responses

This study explores the physiological significance of genetic variants associated with COVID-19 severity using clinical, immunological, and multi-omics data from large cohorts, identifying pathways for prevention and therapy.

An optimized protocol for dual RNA-Seq of human macrophages infected with Mycobacterium avium

This paper presents an optimized dual RNA-Seq protocol for human macrophages infected with Mycobacterium avium to better study host-pathogen interactions.