Jean Gautier

Mechanisms of insertions at a DNA double-strand break

The paper develops Indel-Seq to study insertion mechanisms at DNA double-strand breaks, finding insertions arise from transcription and require DNA-PK and ssDNA overhangs.

Transcription Coupled Repair of DNA Interstrand Crosslinks by UVSSA

This study identifies UVSSA's role in transcription-coupled repair of DNA interstrand crosslinks and links its expression to chemotherapy resistance in cancer cells.

ARP2/3- and resection-coupled genome reorganization facilitates translocations

The paper shows that ARP2/3-dependent nuclear actin polymerization and DNA end-resection coordinate genome reorganization to facilitate homology-directed repair and prevent translocations.

Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex

This study identifies the SWS1-SWSAP1-SPIDR complex as a regulator of distinct homologous recombination pathways, with specific roles in inter-homolog HDR and cancer-related genomic instability.