This study identifies circulating inflammatory ILC2s as a biomarker for gastric cancer progression, showing their association with disease severity and potential for early detection.

bioRxiv · May 1, 2026 · PreprintCancer Biology

LeGO-Teknik reveals that the neurogenesis pathway is a clone-specific hallmark of brain metastasis in breast cancer

Jean Berthelet, Sam Lee, Michael J. Roach, Sreeja R. Gadiaplly, Nora Liu, Farrah El-Saafin, Yunjian Wu, Caroline Bell, Sharon Li, Andres Vallejo-Pulido, Fernando J. Rossello, Emmanuelle Charafe‐Jauffret, Christophe Ginestier, Matthias Ernst, Bhupinder Pal, , Delphine Mérino

The paper identifies neurogenesis-related gene expression as a clone-specific hallmark of brain metastasis in breast cancer using a new optical barcoding tool.

bioRxiv · Jul 23, 2025 · PreprintCancer Biology

A TAK1Cytokine Toxicity Checkpoint Controls Anti-Cancer Immunity

Tirta Mario Djajawi, Anne Huber, S. Rivera, Akash Srivaths, Maede Salehi, Gokhan Gunay, Chloe Gerak, Liam Neil, Oliver Ozaydin, Olivia Voulgaris, Aleen Al Halawani, Daire Gannon, Nooshin Khoshdoozmasouleh, Laura J. Jenkins, Kok Fei Chan, , Conor J. Kearney

This study identifies TAK1 as a cancer-intrinsic checkpoint that limits CD8+ T cell-mediated anti-cancer immunity by suppressing TNF and IFNγ-induced apoptosis, and shows that targeting TAK1 enhances anti-tumor responses.

bioRxiv · May 9, 2025 · PreprintCancer Biology

Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within Interleukin-6 family cytokines

Anne Huber, Amr H. Allam, Christine Dijkstra, Stefan Thiem, Jennifer Huynh, Ashleigh R. Poh, Joshua Konecnik, Saumya P. Jacob, Rita A. Busuttil, Yang Liao, David Chisanga, Wei Shi, Mariah Alorro, Stephen Forrow, Daniele V. F. Tauriello, , Moritz F. Eissmann

This study identifies IL6/STAT3 signaling as a therapeutic target for TP53-mutant gastric cancer by showing its role in metastatic progression driven by mutant Trp53.

Cell Reports · Aug 1, 2024Peer-reviewedCancer Biology