Bromodomain protein IBD1 bridges histone acetylation and H2A.Z deposition to fine-tune transcription and prevent hyperactivation in Tetrahymena thermophila
Zhe Zhang, Haicheng Li, Fan Wei, Aili Ju, Hongzhen Jiang, Fei Ye, Yongqiang Liu, Shan Gao, Yuan‐Yuan Wang
This study identifies IBD1 as a bridge between histone acetylation and H2A.Z deposition, showing its role in maintaining transcriptional homeostasis by preventing hyperactivation.
bioRxiv · Jun 29, 2025 · PreprintGenetics