Manjinder S. Sandhu

African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children

The paper identifies African-specific genetic loci associated with iron status and risk of severe malaria and bacteremia in children, highlighting limited transferability of European polygenic risk scores.

OSBPL11 is an African-specific locus associated with 25-hydroxyvitamin D concentrations and cardiometabolic health

The paper identifies a novel genetic locus OSBPL11 associated with vitamin D levels and cardiometabolic health in African populations through genome-wide analysis.

Transcriptomics and chromatin accessibility in multiple African population samples

The paper identifies novel transcripts, eQTLs, and caQTLs in African populations and fine-maps GWAS signals for complex diseases.

Targeting hepatitis B vaccine escape using immunogenetics in Bangladeshi infants

The paper identifies HLA variants associated with HBV vaccine response in Bangladeshi infants and links them to vaccine escape mechanisms.

Flashfm: A Flexible and Shared Information Fine-mapping Approach for Multiple Quantitative Traits

Flashfm improves fine-mapping of multiple quantitative traits by sharing information between traits, reducing potential causal variants by 20% in a Ugandan cohort.

Polygenic Prediction of Type 2 Diabetes in Continental Africa

This study evaluates if African American or multi-ethnic polygenic risk scores improve type 2 diabetes prediction in continental Africans, finding that African American-derived scores are more predictive.

Insights into human genetic variation and population history from 929 diverse genomes

This study presents 929 high-coverage human genome sequences from 54 populations, revealing new insights into genetic variation and population history.

The transferability of lipid loci across African, Asian and European cohorts

This study assesses the transferability of lipid loci across African, Asian, and European populations, finding high consistency but also population-specific variations.

An Unexpectedly Complex Architecture for Skin Pigmentation in Africans

The paper shows that skin pigmentation in African populations, particularly the KhoeSan, is highly heritable and polygenic, with many new genetic loci identified beyond previously known ones.