Weiming Li

A germline-specific reporter reveals conserved primordial germ cell developmental dynamics between jawless and jawed fish species

This study develops a germline-specific reporter in a jawless vertebrate, revealing conserved germline regulatory mechanisms and PGC dynamics across jawless and jawed species.

Gonadal PIP-seq reveals genes involved in germ cell development and sexual differentiation in sea lamprey ( Petromyzon marinus )

The paper uses PIP-seq to analyze gonadal cell transcriptomes in sea lamprey, identifying gene expression patterns associated with germ cell development and sexual differentiation.

Ancient IL-6-STAT5 signaling orchestrates inflammation in jawless vertebrates

This study identifies IL-6-like genes in jawless vertebrates and shows their role in inflammation through STAT5 signaling and SOCS gene regulation.

Extensive DNA methylome rearrangement during early lamprey embryogenesis

This study investigates DNA methylation dynamics during lamprey embryogenesis, revealing extensive maternal-to-paternal epigenome remodeling and its link to programmed genome rearrangement.

Evolution of a chordate-specific mechanism for myoblast fusion

The paper investigates the evolutionary origins of myoblast fusion mechanisms in chordates, identifying the emergence of Myomaker and Myomixer and their roles in muscle development across species.

Enabling the hypothesis-driven prioritization of ligand candidates in big databases: Screenlamp and its application to GPCR inhibitor discovery for invasive species control

The paper introduces Screenlamp, a toolkit for hypothesis-driven ligand screening, and demonstrates its use in discovering GPCR inhibitors for invasive species control.