β-arrestin recruitment facilitates a direct association with G proteins
Claudia Y. Lee, Jeffrey S. Smith, Taylor Kohlmann, Emily M. Meara, Uyen Pham, Frank Kwarcinski, Andrew N. Dates, Jessica K. Orofino, Issac Choi, Ari S. Hilibrand, Chanpreet Jassal, Abigail Gilmer, Stephen C. Blacklow, Gregory G. Tall, Andrew C. Kruse, Sudarshan Rajagopal
This study shows that G proteins and β-arrestins can directly interact, with Gi family members differing in their association with β-arrestin, and this selectivity is located in the alpha helical domain of Gi.
Nature Communications · Jul 17, 2026Peer-reviewedBiochemistry