Francesco Bedogni

This study tracks neocortical development in organotypic mouse brain slice cultures over five weeks, revealing stable network properties by two weeks and increased variability later, with implications for disease research.

This study shows that enhancing neuronal activity rescues developmental defects in Mecp2 null neurons, improving their maturation and extending lifespan in a mouse model of Rett syndrome.

The paper investigates the synaptic function of somatostatin-expressing interneurons in the striatum, finding they co-release GABA and glutamate to exert both excitatory and inhibitory effects on different postsynaptic targets.