Cleavage of histone H2A during embryonic stem cell differentiation destabilizes nucleosomes to counteract gene activation
Mariel Coradin, Elizabeth G. Poulsen Porter, Francisca N. de Luna Vitorino, Richard M. Searfoss, Joseph Cesare, Yemin Lan, Zhexin Zhu, Peder J. Lund, Simone Sidoli, Yekaterina Perez, Congcong Lu, Justin Brumbaugh, Charles W.M. Roberts, Benjamin Aaron Garcia
The paper shows that cleavage of histone H2A by Cathepsin L during ESC differentiation reduces nucleosome stability and counteracts gene activation.
Journal of Biological Chemistry · Apr 10, 2026Peer-reviewedDevelopmental Biology