Ferrol I. Rome

Sulfur amino acid restriction prevents S-adenosylmethionine-driven liver steatosis, hepatocellular carcinoma, and metabolic remodeling in high-fat-fed GNMT-null mice

This study shows that sulfur amino acid restriction prevents liver steatosis and hepatocellular carcinoma in GNMT-null mice fed a high-fat diet by reducing SAM levels and metabolic dysregulation.

Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis

This study shows that dietary sulfur amino acid restriction improves glucose homeostasis by enhancing hepatic de novo serine synthesis through PSAT1, but not lipid metabolism.

Ketogenesis protects against MASLD-MASH progression through mechanisms that extend beyond overall fat oxidation rate

Mitochondrial citrate metabolism and efflux regulates trophoblast differentiation

This study shows that mitochondrial citrate metabolism and efflux regulate trophoblast differentiation through effects on histone acetylation and gene expression.