Megha K Shah

Structure-based engineering of a nutrient acquisition protein enhances neutralizing antibodies and protection for the development of a gonococcal vaccine

This study engineered a gonococcal antigen to enhance vaccine effectiveness by reducing host factor binding while maintaining structure and immunogenicity.

A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion.

This paper identifies PmSLP as a bacterial surface protein that binds complement factor I to enhance immune evasion by cleaving complement components C3b and C4b without cofactors.