Dixon Ng

This paper designs a minimized TbpB protein to elicit broad protection against meningococcal strains by removing variable loops, showing superior cross-reactivity compared to full-length TbpB.

This study engineered a gonococcal antigen to enhance vaccine effectiveness by reducing host factor binding while maintaining structure and immunogenicity.

This paper identifies PmSLP as a bacterial surface protein that binds complement factor I to enhance immune evasion by cleaving complement components C3b and C4b without cofactors.

This study selects TbpB variants using phylogenetic analysis to create a bivalent vaccine formulation that elicits broad cross-reactive antibodies and shows efficacy against diverse gonococcal strains.

This study evaluates adjuvant effects on vaccine-induced immunity against Neisseria species, showing adjuvant-dependent protection and no correlation between humoral response and protection.

Navargator selects representative variants based on phylogenetic trees to improve cross-reactivity in vaccines, validated using immunization studies.