Natalie H. Au

This paper designs a minimized TbpB protein to elicit broad protection against meningococcal strains by removing variable loops, showing superior cross-reactivity compared to full-length TbpB.

This study engineered a gonococcal antigen to enhance vaccine effectiveness by reducing host factor binding while maintaining structure and immunogenicity.

This study selects TbpB variants using phylogenetic analysis to create a bivalent vaccine formulation that elicits broad cross-reactive antibodies and shows efficacy against diverse gonococcal strains.