This study analyzes whole genome sequences of 1029 Indian individuals to characterize blood group antigens and alleles, identifying rare phenotypes and comparing them with global populations.

medRxiv · Sep 26, 2023 · PreprintGenetic & Genomic Medicine

Genetic landscape of Human neutrophil antigen variants in India from population-scale genomes

Mercy Rophina, Rahul C. Bhoyar, Mohamed Imran, Vigneshwar Senthivel, Mohit Kumar Divakar, Anushree Mishra, Bani Jolly, Sridhar Sivasubbu, Vinod Scaria

This study reports HNA allele and genotype frequencies in the Indian population using whole genome sequencing, finding significant differences in HNA5 variant prevalence compared to other global populations.

HLA · Dec 11, 2022Peer-reviewedGenomics

Genetic variants of human platelet antigens in the Indian population from 1029 whole genomes

Mercy Rophina, Rahul C. Bhoyar, Mohamed Imran, Vigneshwar Senthivel, Mohit Kumar Divakar, Anushree Mishra, Bani Jolly, Sridhar Sivasubbu, Vinod Scaria

The paper analyzes genetic variants of human platelet antigens in 1029 Indian genomes to determine allele frequencies and compare them to global populations.

bioRxiv · Oct 29, 2022 · PreprintGenomics

Comprehensive assessment of Indian variations in the druggable kinome landscape highlights distinct insights at the sequence, structure and pharmacogenomic stratum

Gayatri Panda, Neha Mishra, Disha Sharma, Rintu Kutum, Rahul C. Bhoyar, Abhinav K. Jain, Mohamed Imran, Vigneshwar Senthilvel, Mohit Kumar Divakar, Anushree Mishra, Parth Garg, Priyanka Banerjee, Sridhar Sivasubbu, Vinod Scaria, Arjun Ray

This study analyzes Indian genetic variations in the kinome to identify sequence, structural, and pharmacogenomic differences compared to global datasets, highlighting implications for drug safety and adverse reactions.

Frontiers in Pharmacology · Jul 5, 2022Peer-reviewedGenomics

Spatio-temporal dynamics of intra-host variability in SARS-CoV-2 genomes

Ankit Kumar Pathak, Gyan Prakash Mishra, Bharathram Uppili, Safal Walia, Saman Fatihi, Tahseen Abbas, Sofia Banu, Arup Ghosh, Amol M. Kanampalliwar, Atimukta Jha, Sana Fatma, Shifu Aggarwal, Mahesh Shanker Dhar, Robin Marwal, Venkatraman Srinivasan Radhakrishnan, , Mitali Mukerji

The paper analyzes intra-host Single Nucleotide Variations (iSNVs) in SARS-CoV-2 genomes across multiple time points and regions, finding that many iSNVs later become population-level variants and some may contribute to immune escape.

Nucleic Acids Research · Jan 13, 2022Peer-reviewedGenomics

Whole Genome Sequencing identifies novel structural variant in a large Indian family affected with X - linked agammaglobulinemia

Abhinav K. Jain, Geeta Madathil Govindaraj, Athulya Edavazhippurath, Nabeel Valappil Faisal, Rahul C. Bhoyar, Vishu Gupta, Ramya Uppuluri, Shiny Padinjarayil Manakkad, Atul Kashyap, Anoop Kumar, Mohit Kumar Divakar, Mohamed Imran, Sneha Sawant, Aparna Dhondi Dalvi, Krishnan Chakkiyar, , Vinod Scaria

The paper identifies a novel 5,296 bp deletion in the BTK gene in an Indian family with X-linked agammaglobulinemia through whole genome sequencing and carrier screening.

PLoS ONE · Jul 12, 2021Peer-reviewedGenetic & Genomic Medicine

Initial insights into the genetic epidemiology of SARS-CoV-2 isolates from Kerala suggest local spread from limited introductions

Chandni Radhakrishnan, Mohit Kumar Divakar, Abhinav K. Jain, Prasanth Viswanathan, Rahul C. Bhoyar, Bani Jolly, Mohamed Imran, Disha Sharma, Mercy Rophina, Gyan Ranjan, Paras Sehgal, Beena Philomina Jose, Rajendran V Raman, Nallaveettil Kesavan Thulaseedharan, Kalpana George, , Vinod Scaria

The paper analyzes SARS-CoV-2 isolates from Kerala, India, identifying 166 unique variants, including 4 novel ones, and reports on their genetic epidemiology and potential impact on diagnostics.

Frontiers in Genetics · Mar 17, 2021Peer-reviewedGenomics

High throughput detection and genetic epidemiology of SARS-CoV-2 using COVIDSeq next generation sequencing

Rahul C. Bhoyar, Abhinav K. Jain, Paras Sehgal, Mohit Kumar Divakar, Disha Sharma, Mohamed Imran, Bani Jolly, Gyan Ranjan, Mercy Rophina, Sumit Sharma, Sanjay Siwach, Kavita Pandhare, Swayamprabha Sahoo, Maheswata Sahoo, Ananya Nayak, , Sridhar Sivasubbu

This study evaluates the COVIDSeq protocol for SARS-CoV-2 detection and genetic epidemiology, showing high concordance with RT-PCR and identifying novel variants and lineages.

PLoS ONE · Feb 17, 2021Peer-reviewedGenomics

Insights from Genomes and Genetic Epidemiology of SARS-CoV-2 isolates from the state of Andhra Pradesh

Pallavali Roja Rani, Mohamed Imran, Juturu Vijaya Lakshmi, Bani Jolly, S. Afsar, Abhinav K. Jain, Mohit Kumar Divakar, Panyam Suresh, Disha Sharma, Nambi Rajesh, Rahul C. Bhoyar, Dasari Ankaiah, Sanaga Shanthi Kumari, Gyan Ranjan, Valluri Anitha Lavanya, , Sridhar Sivasubbu

This study sequenced SARS-CoV-2 genomes from Andhra Pradesh, identifying 564 variants including 15 novel ones and 4 associated with increased infectivity.

Epidemiology and Infection · Jan 1, 2021Peer-reviewedGenomics

Genetic epidemiology of variants associated with immune escape from global SARS-CoV-2 genomes

Bani Jolly, Mercy Rophina, Afra Shamnath, Mohamed Imran, Rahul C. Bhoyar, Mohit Kumar Divakar, Pallavali Roja Rani, Gyan Ranjan, Paras Sehgal, Pulala Chandrasekhar, S. Afsar, Juturu Vijaya Lakshmi, Avileli Surekha, Sridhar Sivasubbu, Vinod Scaria

The paper investigates the genetic epidemiology of immune escape variants in SARS-CoV-2 genomes globally.

bioRxiv · Dec 24, 2020 · PreprintBioinformatics