Author

Marianne Lehmann

Biochemistry Research Institute of La Plata

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Developmental Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:rat· 6 Research Focus:differential expression· 5 Assay:DNA methylation· 5 Approach:statistical model· 5 Approach:experimental assay· 1 Organism:human· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Martina Canatelli-MallatiD· 5 shared Priscila ChiavelliniiD· 5 shared Steve HorvathiD· 5 shared Claudia Beatriz HereñúiD· 4 shared Joseph Alan ZolleriD· 4 shared Rodolfo Gustavo GoyaiD· 4 shared Juozas GordevičiusiD· 3 shared Maria D. Gallardo· 3 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersNeuroscience

Martina Canatelli-MallatORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

COGNITIVE REJUVENATION IN OLD RATS BY HIPPOCAMPAL OSKM GENE THERAPY

Steve Horvath, Ezequiel Lacunza, Martina Canatelli-Mallat, Enrique Leo Portiansky, Maria D. Gallardo, Robert T. Brooke, Priscila Chiavellini, Diana C. Pasquini, Mauricio Girard, Marianne Lehmann, Yan Qi, Ake Tzu-Hui Lu, Amin Haghani, Juozas Gordevičius, Martı́n C. Abba, Rodolfo G. Goya

This study shows that OSKM gene therapy in old rats improves spatial learning and memory, reduces epigenetic age, and reverses age-related DNA methylation changes in the hippocampus.

GeroScience · Jul 22, 2024Peer-reviewedNeuroscience

Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction

Steve Horvath, Kavita Singh, Ken Raj, Shraddha I. Khairnar, Akshay Sanghavi, Agnivesh Shrivastava, Joseph Alan Zoller, Caesar Z. Li, Claudia Beatriz Hereñú, Martina Canatelli-Mallat, Marianne Lehmann, Siniša Habazin, Mislav Novokmet, Frano Vučković, Leah C. Solberg Woods, , Harold L. Katcher

This study shows that young porcine plasma treatment reduces epigenetic age in multiple rat organs and improves physiological function.

GeroScience · Oct 24, 2023Peer-reviewedDevelopmental Biology

REGENERATIVE GENE THERAPY IN THE HYPOTHALAMUS PROLONGS FERTILITY IN FEMALE RATS

Maria D. Gallardo, Mauricio Girard, Araceli Bigres, Marianne Lehmann, Silvia Susana Rodríguez, Rodolfo Gustavo Goya

This study shows that long-term hypothalamic gene therapy with Yamanaka factors extends fertility in middle-aged female rats by preserving ovarian function and cyclicity.

bioRxiv · May 24, 2023 · PreprintNeuroscience

YOUNG PLASMA REJUVENATES BLOOD DNA METHYLATION PROFILE, PROLONGS MEAN LIFESPAN AND IMPROVES HEALTH IN OLD RATS

Priscila Chiavellini, Martina Canatelli-Mallat, Marianne Lehmann, Joseph Alan Zoller, Juozas Gordevičius, Maria D. Gallardo, Diana C. Pasquini, Ezequiel Lacunza, Claudia Beatriz Hereñú, Gustavo R. Morel, Steve Horvath, Rodolfo G. Goya

This study shows that young rat plasma reduces DNA methylation age, extends lifespan, and improves health in old rats.

bioRxiv · Dec 1, 2022 · PreprintBioinformatics

HIPPOCAMPAL DNA METHYLATION, DNAm AGE AND SPATIAL MEMORY PERFORMANCE IN YOUNG AND OLD RATS

Priscila Chiavellini, Marianne Lehmann, Martina Canatelli-Mallat, Joseph Alan Zoller, Claudia Beatriz Hereñú, Gustavo R. Morel, Steve Horvath, Rodolfo Gustavo Goya

This study examines age-related DNA methylation changes in rat hippocampus and links them to spatial memory performance in young and old rats.

bioRxiv · May 7, 2021 · PreprintNeuroscience

Reversing age: dual species measurement of epigenetic age with a single clock

Steve Horvath, Kavita Singh, Ken Raj, Shraddha I. Khairnar, Akshay Sanghavi, Agnivesh Shrivastava, Joseph Alan Zoller, Caesar Z. Li, Claudia Beatriz Hereñú, Martina Canatelli-Mallat, Marianne Lehmann, Leah C. Solberg Woods, Angel Garcia Martinez, Tengfei Wang, Priscila Chiavellini, , Harold L. Katcher

This study develops epigenetic clocks for rat and human tissues and shows that young plasma treatment reduces epigenetic age in multiple tissues and improves organ function.

bioRxiv · May 7, 2020 · PreprintDevelopmental Biology