Martina Canatelli-Mallat

COGNITIVE REJUVENATION IN OLD RATS BY HIPPOCAMPAL OSKM GENE THERAPY

This study shows that OSKM gene therapy in old rats improves spatial learning and memory, reduces epigenetic age, and reverses age-related DNA methylation changes in the hippocampus.

Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction

This study shows that young porcine plasma treatment reduces epigenetic age in multiple rat organs and improves physiological function.

YOUNG PLASMA REJUVENATES BLOOD DNA METHYLATION PROFILE, PROLONGS MEAN LIFESPAN AND IMPROVES HEALTH IN OLD RATS

This study shows that young rat plasma reduces DNA methylation age, extends lifespan, and improves health in old rats.

HIPPOCAMPAL DNA METHYLATION, DNAm AGE AND SPATIAL MEMORY PERFORMANCE IN YOUNG AND OLD RATS

This study examines age-related DNA methylation changes in rat hippocampus and links them to spatial memory performance in young and old rats.

Reversing age: dual species measurement of epigenetic age with a single clock

This study develops epigenetic clocks for rat and human tissues and shows that young plasma treatment reduces epigenetic age in multiple tissues and improves organ function.