Neil Donald Sargison

Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta

The paper generates a chromosome-scale genome assembly for Teladorsagia circumcincta and identifies genetic loci associated with drug resistance to improve anthelmintic resistance diagnostics.

Genomic landscape of drug response reveals novel mediators of anthelmintic resistance

The paper maps resistance loci for three anthelmintic classes in a parasitic nematode, identifies novel alleles for benzimidazoles and levamisole, and implicates cky-1 in ivermectin resistance.

Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and recovery in a parasitic nematode

This paper identifies gene expression changes associated with ivermectin resistance in parasitic nematodes through genetic crosses and RNA-seq, revealing upregulation of specific genes linked to neuronal plasticity and chloride homeostasis.

Genetic models suggest single and multiple origins of dihydrofolate reductase mutations in Plasmodium vivax

The paper uses genetic modeling to analyze the evolutionary origins of dihydrofolate reductase mutations in Plasmodium vivax, finding single and multiple origins for different mutations.

Extensive genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm

The paper presents a high-quality, chromosome-scale genome assembly of Haemonchus contortus using long-read sequencing, revealing genetic diversity and transcriptional regulation.

Contrasting population genetics of cattle- and buffalo- derived Theileria annulata causing tropical theileriosis

The paper compares the genetic diversity of Theileria annulata in cattle and water buffalo in Pakistan, finding higher diversity in cattle-derived populations.

Genetic analysis confirms the presence of Dicrocoelium dendriticum in the Himalaya ranges of Pakistan.

The paper confirms the presence of Dicrocoelium dendriticum in the Himalaya ranges of Pakistan using genetic analysis of flukes collected from the Chitral valley.

A novel metabarcoded DNA sequencing tool for the detection of Plasmodium species in malaria positive patients

The paper introduces a metabarcoded DNA sequencing method for detecting Plasmodium species in human malaria patients, showing improved diagnostic performance compared to an immunochromatographic assay.

Genetic diversity and multiplicity of infection in Fasciola gigantica isolates of Pakistani livestock

The paper analyzes genetic diversity and multiplicity of infection in Fasciola gigantica isolates from Pakistani livestock using mt-ND-1 locus sequencing.

Evidence for the F200Y (TAC) mutation conferring benzimidazole resistance in a southern USA cattle population of Haemonchus placei spreading from a single emergence

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

The paper identifies a single major QTL on chromosome V associated with ivermectin resistance in Haemonchus contortus through genome-wide analysis of genetic crosses.

Development of high throughput methods for the analysis of anthelmintic resistance allele frequencies in field populations of gastrointestinal nematodes.

The paper develops a high-throughput method to determine anthelmintic resistance allele frequencies in gastrointestinal nematodes using Illumina Mi-seq sequencing.

Emergence and the spread of the F200Y benzimidazole resistance mutation in Haemonchus contortus and Haemonchus placei from buffalo and cattle

The paper identifies the F200Y mutation as a common benzimidazole resistance mutation in Haemonchus contortus and H. placei in buffalo and cattle, showing multiple emergence events in H. contortus and a single emergence in H. placei.

A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry

This paper constructs a genetic map of Haemonchus contortus using whole-genome resequencing, revealing recombination patterns and reproductive traits like polyandry and polyploidy.