Mariano Avino

Dysregulation of an H3K79me2-dependent epigenetic barrier impairs neural progenitor cell proliferation and differentiation in Fragile X syndrome

This study identifies an H3K79me2-dependent epigenetic barrier in FXS neural progenitor cells, showing its dysregulation impairs proliferation and differentiation.

Ketogenic interventions prevent alterations of the gut microbiome in transgenic Alzheimer Disease mice

This study shows ketogenic diets restore gut microbiome alterations in Alzheimer's mice by reducing Bifidobacterium and increasing short-chain fatty acid-producing bacteria.

More is better: A simple antibody-based strategy for recovering all major mouse brain cell types from multiplexed single-cell RNAseq samples.

The paper introduces a multiplexing strategy for scRNA-seq of adult mouse brain samples using anti-Thy1.2 antibodies and secondary oligonucleotide-labeled antibodies, enabling pooled sequencing with efficient demultiplexing and cost reduction.

Impact of in vivo cyclic reprogramming on the choroid plexus

This study investigates the effects of cyclic in vivo OSKM reprogramming on the choroid plexus, finding limited transcriptomic changes but increased NKCC1 expression and minor morphological alterations.

Tracking the progression of Alzheimer's disease with peripheral blood monocytes

This study identifies differentially expressed genes in peripheral blood monocytes across Alzheimer's disease stages, highlighting chemokine/cytokine pathways and potential biomarkers for early detection.

An open-source k-mer based machine learning tool for fast and accurate subtyping of HIV-1 genomes

The paper introduces an open-source, alignment-free k-mer based tool for accurate and fast HIV-1 subtype classification, achieving 97% accuracy and outperforming existing methods in speed and privacy.