Author

Mélanie Plourde

Université de SherbrookeORCID 0000-0002-1575-2825Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

Karl J. L. FernandesiD· 3 shared Anne Aumont· 2 shared Annick Vachon· 2 shared Jessica Avila LopeziD· 2 shared Marian Mayhue· 2 shared Marta TurriiD· 2 shared Myriam Aubin· 2 shared Anne Castonguay· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersNeuroscience

Karl J. L. FernandesORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

In vivo inhibition of stearoyl-CoA desaturase modulates the hippocampal fatty acid profile and restores density of dendritic spines in the aggressive 5xFAD model of Alzheimer s disease

Marta Turri, Myriam Aubin, Anne Aumont, Annick Vachon, Jessica Avila Lopez, Marian Mayhue, Mélanie Plourde, Karl J. L. Fernandes

This study shows that inhibiting SCD improves fatty acid profiles and restores dendritic spine density in a 5xFAD Alzheimer's model.

bioRxiv · Aug 27, 2025 · PreprintNeuroscience

Ketogenic interventions restore cognition and modulate peripheral metabolic dysfunctions in Alzheimer's disease mouse models

Paule E. H. M’Bra, Laura K. Hamilton, Gaël Moquin‐Beaudry, Myriam Aubin, Chenicka Lyn Mangahas, Federico Pratesi, Elsa Brunet‐Ratnasingham, Anne Castonguay, Sophia Mailloux, Manon Galoppin, Megan Bernier, Marta Turri, Annick Vachon, Marian Mayhue, Anne Aumont, , Karl J. L. Fernandes

This study shows that two ketogenic diets improve cognition and metabolic health in Alzheimer's disease mouse models, with distinct effects on peripheral metabolism.

bioRxiv · Sep 4, 2024 · PreprintNeuroscience

Impact of in vivo cyclic reprogramming on the choroid plexus

Jessica Avila Lopez, Clauda Abboud, Maged Ibrahim, Javier Rocha Ahumada, Mariano Avino, Mélanie Plourde, Karl J. L. Fernandes, C. Florian Bentzinger, Benoît Laurent

This study investigates the effects of cyclic in vivo OSKM reprogramming on the choroid plexus, finding limited transcriptomic changes but increased NKCC1 expression and minor morphological alterations.

bioRxiv · Feb 28, 2023 · PreprintNeuroscience