Karim Majzoub

This study identifies the RIG-I/MDA5-MAVS-IRF3 axis as the pathway sensing TONV infection and activating the IFN-I response to restrict viral replication.

The paper identifies DNA-PKcs as a regulator of cyclic dinucleotide signaling, showing it interacts with CDN and modulates STING activation and antiviral responses.

This study shows deltaviruses use helper virus particles as Trojan Horses for cell entry, revealing a new mode of viral transmission.

This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.

The paper identifies polyadenylated viral transcripts as the primary targets of the Drosophila siRNA pathway during RNA virus infection, rather than viral genomes.

The paper identifies N-glycan modifications on mammalian Y RNAs, showing RNA can be a scaffold for glycosylation in the secretory pathway.

This study identifies novel MHC-I antigens specific to dengue virus infection using an immuno-proteomics approach, revealing ligands associated with distinct HLA haplotypes and T-cell recognition.