Author

James B. Hurley

University of WashingtonORCID 0000-0002-7754-0705Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Genomics· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Daniel T. HassiD· 3 shared Jennifer R. ChaoiD· 2 shared Abbi L. EngeliD· 1 shared Anders Knudsen· 1 shared Antonia Fottner· 1 shared Aspen Tong· 1 shared Aykut DemirkoliD· 1 shared Boyuan Wang· 1 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCell Biology

Daniel T. HassORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A synthetic PGC1α co-activator reprograms microglial immunometabolism to preserve cone function in retinal degeneration

Thomas Winogrodzki, Jayvin Hernandez-Reyes, Rajvir Mukesh Solanky, Richard Lowery, Georgy Komissarov, Wen Huang, Boyuan Wang, Neoklis Makrides, Sharifa Davis, Siyuan Liu, Yong-Shi Li, Wen-Hsuan Wu, Nicholas Nolan, Robert P. van de Werken, Aykut Demirkol, , Stephen H. Tsang

bioRxiv · Oct 5, 2026 · PreprintImmunology

Chronic Hypoxic Signalling Reprograms Metabolism and Alters Redox and Lipid Homeostasis in Rod Photoreceptors

Larissa P. Govers, Daniel T. Hass, Martin‐Paul Agbaga, Claudia Matter, Antonia Fottner, Marijana Samardzija, James B. Hurley, Christian Grimm

This study investigates how chronic hypoxia reprograms metabolism and alters redox and lipid homeostasis in rod photoreceptors using a mouse model.

bioRxiv · Jul 8, 2026 · PreprintNeuroscience

Nutrient Microenvironments Reprogram Pigment Epithelium Metabolism and Phenotype

Rayne R. Lim, Emily Zhao, Daniel T. Hass, Yekai Wang, Mark Eminhizer, Davide Ortolan, Sheldon Niernberger, Aspen Tong, Bree R Nelson, Marcos Nazario, Vishya Adipudi, Kapil Bharti, James B. Hurley, Jianhai Du, Jennifer R. Chao

This study examines how different nutrient microenvironments affect RPE cell phenotype, function, and metabolism in iPSC and fetal RPE, identifying key metabolic shifts and phenotypic changes.

bioRxiv · Jul 7, 2026 · PreprintCell Biology

Reassessing Retinal Pigment Epithelial Ketogenesis: Enzymatic Assays for Ketone Body Levels Provide Inaccurate Results

Gillian A Gulette, Daniel T. Hass, Kriti Pandey, Qitao Zhang, John Y S Han, Abbi L. Engel, Jennifer R. Chao, Nancy J. Philp, James B. Hurley, Jason M. L. Miller

This study shows that enzymatic assays overestimate β-hydroxybutyrate (β-HB) in RPE cultures, while mass spectrometry reveals equal apical and basal secretion and β-HB sources from fatty acids and amino acids.

Experimental Eye Research · Jun 10, 2024Peer-reviewedCell Biology

Multi-tissue landscape of somatic mtDNA mutations indicates tissue specific accumulation and removal in aging

Mónica Sánchez-Contreras, Mariya T. Sweetwyne, Kristine A. Tsantilas, Jeremy A. Whitson, Matthew D. Campbell, Brendan F. Kohrn, Hyeon Jeong Kim, Michael J. Hipp, Jeanne Fredrickson, Megan M. Nguyen, James B. Hurley, David Joseph Marcinek, Peter S. Rabinovitch, Scott R. Kennedy

The paper detects age-related tissue-specific accumulation of mtDNA mutations in mice and shows oxidative damage mutations are reduced with treatment.

eLife · Feb 17, 2023Peer-reviewedGenomics