Author

William E. Barclay

National Institutes of HealthORCID 0000-0002-6910-9157Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 3 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

Meng‐meng FuiD· 2 shared Dharshini GopaliD· 1 shared Dorothy P. SchaferiD· 1 shared Enrique ÁlvareziD· 1 shared Eva NogalesiD· 1 shared George S. MelchoriD· 1 shared Jason R. PlemeliD· 1 shared Jeffrey K. HuangiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Meng‐meng FuORCID

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3 papers

Recent·Most cited

Spatially patterned cytoskeletal organization shapes astrocyte branch complexity

Meghan E. Wynne, William E. Barclay, Dharshini Gopal, Naznin Jahan, Johanna J. D. Bergstrom, Lana T Ho, Eva Nogales, Meng‐meng Fu

This study investigates the cytoskeletal organization of astrocytes and shows how microtubule and actin structures contribute to their complex branching morphology.

bioRxiv · Oct 10, 2025 · PreprintNeuroscience

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

Phillip S. Gross, Violeta Durán‐Laforet, Lana T. Ho, George S. Melchor, Sameera Zia, Zeeba Manavi, William E. Barclay, Sung Hyun Lee, Nataliia V. Shults, Sean Selva, Enrique Álvarez, Jason R. Plemel, Meng‐meng Fu, Dorothy P. Schafer, Jeffrey K. Huang

This study shows that senescent microglia impair remyelination in young mice but not aged mice, with CCL11 in SASP inhibiting oligodendrocyte maturation.

Nature Communications · Mar 7, 2025Peer-reviewedNeuroscience

Annexin-A1 tripeptide attenuates surgery-induced neuroinflammation and memory deficits through regulation of the NLRP3 inflammasome

Zhiquan Zhang, Qing Ma, Ravikanth Velagapudi, William E. Barclay, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Mari L. Shinohara, Niccolò Terrando

This study investigates the role of the NLRP3 inflammasome in postoperative neuroinflammation and evaluates the neuroprotective effects of the ANXA1-derived peptide ANXA1sp in a mouse model of surgery-induced cognitive deficits.

Frontiers in Immunology · May 6, 2022Peer-reviewedNeuroscience