Author

Vibhor Mishra

Howard Hughes Medical InstituteORCID 0000-0002-4846-4790Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Arabidopsis· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Organism:plant (other)· 1 Assay:proteomics· 1

Frequent Co-Authors

Akihito FukudomeiD· 2 shared Craig S. PikaardiD· 2 shared Jasleen Singh· 2 shared Alex KentsisiD· 1 shared Ali KhalighifariD· 1 shared Andrew LofferiD· 1 shared Aurelie ClaquiniD· 1 shared Bappaditya ChandraiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Akihito FukudomeORCID

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3 papers

Recent·Most cited

MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia

Nicole Lynn Michmerhuizen, Emily Heikamp, Ilaria Iacobucci, Masayuki Umeda, Bright Arthur, Vibhor Mishra, Chun Shik Park, Danika Di Giacomo, Ryan Hiltenbrand, Qingsong Gao, Sandi Radko-Juettner, Josi Lott, Cynthia Martucci, Varsha Subramanyam, Charlie Hatton, , Charles Grenfell Mullighan

This study identifies MOZ and HBO1 as molecular dependencies in NUP98-rearranged AML, showing their inhibition reduces leukemic burden and synergizes with Menin inhibitors.

Cancer Discovery · Jun 19, 2025Peer-reviewedCancer Biology

A DCL3 dicing code within Pol IV-RDR2 transcripts diversifies the siRNA pool guiding RNA-directed DNA methylation

Andrew Loffer, Jasleen Singh, Akihito Fukudome, Vibhor Mishra, Feng Wang, Craig S. Pikaard

The paper shows that Pol IV and RDR2 transcript features determine siRNA size, sequence, and strand polarity, enhancing DNA methylation coverage.

eLife · Jan 31, 2022Peer-reviewedMolecular Biology

Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2

Akihito Fukudome, Jasleen Singh, Vibhor Mishra, Eswar R. Reddem, Francisco Martínez-Márquez, Sabine Wenzel, Rui Yan, Momoko Shiozaki, Zhiheng Yu, Joseph Che‐Yen Wang, Yuichiro Takagi, Craig S. Pikaard

This paper reports the structure of Arabidopsis RDR2 and shows how it initiates transcription from RNA templates displaced from RNA-DNA hybrids.

Proceedings of the National Academy of Sciences · Dec 13, 2021Peer-reviewedMolecular Biology