Author

Fermin M. Sanchez-Guijo

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-7076-7739Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Ana Alfonso PiérolaiD· 2 shared Diego AlignaniiD· 2 shared Felipe PrósperiD· 2 shared Guillermo SerranoiD· 2 shared Mikel HernáeziD· 2 shared Patxi San Martín‐ÚriziD· 2 shared Aina Oliver‐CaldésiD· 1 shared Aintzane Díaz-Mazkiaran· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersGenomics

Ana Alfonso PiérolaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeting SOS1 synergistically enhances efficacy of BCR/ABL tyrosine kinase inhibitors and overcomes resistance in chronic myeloid leukemia

Rósula García‐Navas, Carmela Gómez, Anabel Clemente-Serrano, Belen Zamora-Valdivieso, Sara Pérez-Gutiérrez, Andrea Olarte-San Juan, Alba Díaz-Aguilera, Sonsoles Calvo-Jimenez, Nuria Calzada, Alberto Fernández‐Medarde, Magdalena Sierra, Fermin M. Sanchez-Guijo, Dolors Colomer, Robyn L. Schenk, Marco H. Hofmann, , Eugenio Santos

This study shows that combining SOS1 inhibitor BI-3406 with BCR/ABL TKIs like imatinib improves survival and overcomes resistance in CML models.

Cell Death and Disease · Aug 12, 2026Peer-reviewedCancer Biology

Single-Cell Multiomics Reveals Regulatory Mechanisms of CAR T Cell Persistence and Dysfunction in Multiple Myeloma

Lorea Jordana-Urriza, Guillermo Serrano, Sergio Camara-Peña, María Eréndira Calleja-Cervantes, Patxi San Martín‐Úriz, Aintzane Zabaleta, Aina Oliver‐Caldés, Marta Español‐Rego, Diego Alignani, Teresa Lozano, Saray Rodríguez-Diaz, Elena Iglesias, V. Cabañas, Juan Luis Reguera, Verónica González‐Calle, , Felipe Prósper

This study uses single-cell multiomics to analyze CAR T cell dynamics in multiple myeloma, identifying regulatory mechanisms affecting persistence and dysfunction.

Blood Neoplasia · Feb 5, 2026Peer-reviewedGenomics

Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single cell resolution

Marina Ainciburu, Teresa Ezponda, Nerea Berastegui, Ana Alfonso Piérola, Amaia Vilas‐Zornoza, Patxi San Martín‐Úriz, Diego Alignani, José María Lamo-Espinosa, Mikel San-Julián, Tamara Jiménez, Félix López, Sandra Muntión, Fermin M. Sanchez-Guijo, Antonieta Molero, María Julia Montoro, , Felipe Prósper

This study uses single-cell RNA sequencing to analyze changes in hematopoietic stem and progenitor cells during aging and myeloid malignancies, identifying altered gene expression and regulatory networks.

eLife · Jan 11, 2023Peer-reviewedGenomics

Splice donor site sgRNAs enhance CRISPR/Cas9-mediated knockout efficiency

Ignacio García‐Tuñón, Verónica Alonso-Pérez, Elena Vuelta, Sandra Pérez‐Ramos, María Herrero, Lucía Méndez, Jesús María Hernández-Sánchez, Marta Martín‐Izquierdo, Raquel Saldaña, Julián Sevilla, Fermin M. Sanchez-Guijo, Jesús María Hernández‐Rivas, Manuel Sánchez‐Martín

This study shows that targeting splice donor sites with sgRNAs improves CRISPR/Cas9 knockout efficiency by increasing frameshift mutations and disrupting pre-mRNA splicing.

PLoS ONE · May 9, 2019Peer-reviewedMolecular Biology