Author

Timothy J. Hark

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Jeffrey N. SavasiD· 3 shared Amy P RappiD· 1 shared Anirvan Ghosh· 1 shared Anis ContractoriD· 1 shared Arun UpadhyayiD· 1 shared Daniel B. McClatchyiD· 1 shared Edward H. KooiD· 1 shared Eliezer MasliahiD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersNeuroscience

Jeffrey N. SavasORCID

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3 papers

Recent·Most cited

Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer's disease models

Nalini R. Rao, Olivia A. DeGulis, Toshihiro Nomura, SeungEun Lee, Timothy J. Hark, Justin C. Dynes, Emily X. Dexter, Maciej Dulewicz, Junyue Ge, Arun Upadhyay, Eugenio F. Fornasiero, Robert J. Vassar, Jörg Hanrieder, Anis Contractor, Jeffrey N. Savas

The paper discovers that levetiracetam prevents Aβ42 production by modulating synaptic vesicle cycling, altering APP localization, and favoring non-amyloidogenic processing in Alzheimer's disease models.

bioRxiv · Oct 28, 2024 · PreprintNeuroscience

Sex-Dependent Effects of Chronic Microdrive Implantation on Acquisition of Trace Eyeblink Conditioning

Amy P Rapp, Timothy J. Hark, John Power, Jeffrey N. Savas, Myongsoo Matthew Oh, John F. Disterhoft

This study investigates sex-dependent effects of chronic microdrive implantation on trace eyeblink conditioning in mice, finding that males learned faster than females with implants, but not with dummy implants.

Neurobiology of Learning and Memory · Jun 9, 2022Peer-reviewedNeuroscience

Amyloid accumulation drives proteome-wide alterations in mouse models of Alzheimers disease like pathology

Jeffrey N. Savas, Yizhi Wang, Laura A. DeNardo, Salvador Martínez‐Bartolomé, Daniel B. McClatchy, Timothy J. Hark, Natalie F. Shanks, Kira Cozzolino, Mathieu Lavallée‐Adam, Samuel N. Smukowski, Sung Kyu Park, Jeffery W. Kelly, Edward H. Koo, Terunaga Nakagawa, Eliezer Masliah, , John R. Yates

The paper identifies proteome-wide changes in mouse models of Alzheimer's disease, highlighting ApoE dysregulation and synaptic protein loss.

Cell Reports · Nov 1, 2017Peer-reviewedNeuroscience