Author

Luiz Ricardo C. Vasconcellos

The Francis Crick InstituteORCID 0000-0002-3877-7013Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

Aarushi SinghaliD· 1 shared Abderrahman HachaniiD· 1 shared Alain FillouxiD· 1 shared Alba Bosquet Agudo· 1 shared Alejandro Suárez‐BonnetiD· 1 shared Bart VanhaesebroeckiD· 1 shared Bénédicte ManouryiD· 1 shared Brigitta StockingeriD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperPathology

Aarushi SinghalORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Branched actin networks mediate macrophage-dependent host microbiota homeostasis.

Luiz Ricardo C. Vasconcellos, Shaina Chor Mei Huang, Alejandro Suárez‐Bonnet, Simon Lawrence Priestnall, Probir Chakravarty, Sunita Varsani-Brown, Matthew L. Winder, Kathleen Shah, Naoko Kogata, Brigitta Stockinger, Michael Way

This study shows that Arpc5-containing Arp2/3 complexes are critical for macrophage function and maintaining host-microbiota homeostasis, as their loss leads to intestinal inflammation.

Science · Nov 13, 2025Peer-reviewedImmunology

PI3Kδ Bridges Microbial Surveillance with Antigen Presentation to Reinforce Intestinal Immunity

Maria Gonzalez-Nuñez, Luiz Ricardo C. Vasconcellos, José Garrido‐Mesa, Rafael Cardoso Maciel Costa Silva, Abderrahman Hachani, Alba Bosquet Agudo, Raffaele Simeoli, Laura Medrano Gonzalez, Alain Filloux, Heidi C. E. Welch, Mauro Perretti, Bart Vanhaesebroeck, David Dombrowicz, Oliver Haworth, Klaartje Bel Kok, , Ezra Aksoy

This study shows PI3Kδ is critical for dendritic cell function in intestinal immunity by linking microbial sensing to antigen presentation and T-cell activation.

bioRxiv · May 13, 2025 · PreprintImmunology

Impaired Macrophage DNase Secretion Promotes Neutrophil Extracellular Trap Mediated Defective Efferocytosis in Atherosclerosis

Umesh Kumar Dhawan, Tanwi Vartak, Hanna Englert, Aarushi Singhal, Rahul Chakraborty, Karran Kiran Bhagat, Luiz Ricardo C. Vasconcellos, Ciarán McDonnell, Mary Connolly, Edward Mulkern, Martin K. O’Donohoe, Mathias Gelderblom, Thomas Renné, Catherine Godson, Eoin Patrick Brennan, Manikandan Subramanian

This study identifies impaired macrophage DNase secretion due to ER stress as a mechanism leading to NET persistence and defective efferocytosis in atherosclerosis.

bioRxiv · Jan 30, 2025 · PreprintPathology