This study assesses cross-neutralisation of sarbecoviruses by COVID-19 vaccines in older adults, finding reduced neutralisation of Omicron variants and some animal sarbecoviruses but enhanced neutralisation of specific bat and pangolin coronaviruses.

npj Vaccines · Jul 1, 2026Peer-reviewedMicrobiology

Circulating pre-osteoclasts are primed for osteoclast fate and synovial tissue homing in psoriatic arthritis.

Joseph Hutton, Atrik Saha, Qian Li, Neda Farahi, Francesca A. A. Leek, Stephen McDonnell, Busola Ade-Ojo, Daniel Gillett, Nicholas Shenker, Deepak Rohit Jadon, Anna Laddach, Charlotte Summers, Naomi N. McGovern

bioRxiv · Mar 24, 2026 · PreprintImmunology

Elucidating mechanisms of genetic cross-disease associations: an integrative approach implicates protein C as a causal pathway in arterial and venous diseases

David Stacey, Lingyan Chen, Joanna M. M. Howson, Amy M. Mason, Stephen Burgess, Stephen G. MacDonald, Jonathan Langdown, Harriet McKinney, Kate Downes, Neda Farahi, James E. Peters, Saonli Basu, James S. Pankow, Nathan Pankratz, Weihong Tang, , Dirk S. Paul

The paper identifies a genetic variant in PROCR that influences protein C and factor VII levels, linking it to both reduced coronary artery disease risk and increased venous thromboembolism risk through opposing inflammatory and thrombotic mechanisms.

medRxiv · Mar 16, 2020 · PreprintGenetic & Genomic Medicine