The paper characterizes a Grin1Q536R/+ mouse model carrying a GRIN1 variant, showing age- and sex-dependent behavioral and physiological changes linked to GRIN1-NDD.

bioRxiv · Sep 15, 2026 · PreprintNeuroscience

Metaplastic priming enables non-ionotropic NMDA receptor-mediated synaptic depotentiation in the hippocampus

Quinn Pauli, Juliet Arsenault, Samuel W. Fung, Amy J. Ramsey, Robert P. Bonin

This study shows that the temporal pattern of prior LTP induction affects the molecular pathways involved in depotentiation, with non-ionotropic NMDAR signaling required for compressed LTP depotentiation.

bioRxiv · Feb 28, 2025 · PreprintNeuroscience

Chronic pain mediated changes in the appetitive value of affective touch in mice

Maham Zain, Laura Bennett, Hantao Zhang, Quinn Pauli, Juliet Arsenault, Shajenth Premachandran, Jenny Cheung, Christine Krause Pham, Lexi Wowk, Sékou-Oumar Kaba, Samuel W. Fung, Irene Lecker, Eric W. Salter, Feng Wang, Reza Sharif‐Naeini, , Robert P. Bonin

This study investigates how chronic pain alters the rewarding value of gentle touch in mice by examining neural circuits and behavioral responses.

bioRxiv · Nov 9, 2023 · PreprintNeuroscience