D. Brian Foster

Tuberculous meningitis alters the proteomic landscape of brain-derived extracellular vesicles

This study identifies proteomic changes in brain-derived extracellular vesicles during tuberculous meningitis, revealing shifts toward inflammation and neuronal injury.

Optimized Mn2+-Phos-tag Gels Reveal Sarcomeric Protein Dephosphorylation upon Myofibril Preparation

This paper optimizes Mn2+-Phos-tag SDS-PAGE for cardiac myofilament proteins, showing that myofibril preparation causes significant dephosphorylation of MLC2 and cTnI.

SureQuant IS-PRM Enables Cross-Species Targeted Quantification of Retinoid Metabolism and Signaling Proteins in the Heart

The paper develops a targeted proteomics method to quantify retinoid metabolism and signaling proteins across species and tissues, revealing tissue-specific networks and developmental changes in the heart.

Inhibition of Cardiac p38 Highlights the Role of the Phosphoproteome in Heart Failure Progression

This study investigates the effects of p38 MAPK inhibition on cardiac remodeling in a guinea pig HF model, finding that SB203580 treatment protects cardiac function and phosphoproteome integrity.

Microbial Metagenomes Across a Complete Phytoplankton Bloom Cycle:High-Resolution Sampling Every 4 Hours Over 22 Days

The paper describes a high-resolution microbial metagenome dataset collected over 22 days during a phytoplankton bloom cycle, including gene abundances and time-matched environmental data.

Splenic follicular B cells promote adverse cardiac remodeling after myocardial infarction via MHC II-dependent antigen presentation.

This study shows splenic follicular B cells worsen heart failure after MI by presenting cardiac antigens via MHC II, promoting adverse cardiac remodeling.

The DOE JGI Metagenome Workflow

The paper describes a metagenome processing workflow that includes assembly, annotation, and binning, and provides tools for researchers to apply it to their data.