The paper identifies symmetry-specific readers and anti-readers of 5-formylcytosine (fC) in mammalian DNA using proteomics, revealing how proteins recognize fC-containing CpG dyads with distinct symmetry preferences.

bioRxiv · Apr 12, 2026 · PreprintBiochemistry

Condensin II activation by M18BP1

Alessandro Borsellini, Duccio Conti, Erin Cutts, Rebecca J. Harris, Kai Walstein, Andrea Graziadei, Valentina Cecatiello, Tom F. Aarts, Ren Xie, Abdelghani Mazouzi, Sushweta Sen, Claire Hoencamp, Richard Pleuger, Sabrina Ghetti, Lina Oberste-Lehn, , Alessandro Vannini

The paper identifies M18BP1 as a factor required for condensin II localization to chromatin and shows it competes with MCPH1 to activate condensin II during mitosis.

Molecular Cell · Jul 1, 2025Peer-reviewedCell Biology

Proximity-based activation of AURORA A by MPS1 potentiates error correction

Nelson Leça, Francisca Barbosa, Sergi Rodríguez-Calado, Arianna Esposito-Verza, Margarida Moura, Paulo D. Pedroso, Inês Mendes Pinto, Elena Artes, Tanja Bange, Cláudio E. Sunkel, Marin Barišić, Thomas J. Maresca, Carlos Conde

This study identifies a proximity-based activation mechanism where MPS1 phosphorylates AURORA A kinase to enhance error correction during mitosis.

Current Biology · Jun 13, 2024Peer-reviewedCell Biology

An integrative omics approach reveals posttranscriptional mechanisms underlying circadian temperature compensation

Christoph Schmal, Bert Maier, Reut Ashwal-Fluss, Osnat Bartok, Anna‐Marie Finger, Tanja Bange, Stella Koutsouli, María S. Robles, Sebastián Kadener, Hanspeter Herzel, Achim Kramer

The paper identifies posttranscriptional mechanisms, specifically involving CPSF6 and EIF2S1, that underlie circadian temperature compensation in U-2 OS cells.

bioRxiv · Oct 6, 2021 · PreprintGenomics