Jean Farup

CD90 identifies distinct fractions of muscle stem cells with different modalities of activation and quiescence maintenance

The paper identifies CD90 as a marker distinguishing two muscle stem cell subpopulations with different activation kinetics and quiescence maintenance mechanisms in mice and humans.

Fibro-adipogenic Progenitor and Macrophage Remodeling of the Aging Skeletal Muscle Niche During Exercise-Induced Hypertrophy

This study examines how exercise-induced hypertrophy in older adults alters fibro-adipogenic progenitors (FAPs) and macrophages in skeletal muscle, revealing phenotypic shifts and interactions that support muscle growth.

Defining the Vascular Niche of Human Adipose Tissue Across Metabolic States

The paper creates a single-cell transcriptome atlas of human subcutaneous adipose tissue vascular cells, identifies sub-AdECs, and links their properties to metabolic disease.

Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle

This study identifies distinct roles of AMPKγ isoforms in glucose uptake in skeletal muscle, showing γ1 is required for ADaM site activator-stimulated uptake but not AMP-binding activators.

Pathophysiological remodeling of the skeletal muscle microenvironment in patients with lung cancer

The paper investigates muscle remodeling in NSCLC patients, identifying changes in fibro-adipogenic progenitors, mitochondrial function, and immune cells that contribute to muscle wasting.

In vivo self-renewal and expansion of quiescent stem cells from a non-human primate

The paper identifies and characterizes quiescent stem cells in a non-human primate, showing their in vivo self-renewal and similarity to human cells.

Complementing Muscle Regeneration: Fibro-Adipogenic Progenitor and Macrophage-Mediated Repair of Elderly Human Skeletal Muscle

This study identifies fibro-adipogenic progenitors and macrophages as key players in elderly human skeletal muscle regeneration through spatial and single-cell transcriptomics, revealing their interplay via complement factor C3.

Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets

Portal integrates large-scale single-cell datasets efficiently and accurately by preserving biological variation across samples, platforms, and species.