Oliver Hobert

This study identifies ceh-34 as a key gene specifying enteric nervous system differentiation in C. elegans, showing its role in neuron type-specific programs and circuit assembly.

The paper identifies six CUT homeobox genes that collectively control pan-neuronal gene expression in C. elegans through gene dosage and interaction with neuron-type specific transcription factors.

The paper uses NeuroPAL to visualize and analyze the differentiation of male-specific neurons in C. elegans, showing coordinated terminal differentiation in the fourth larval stage.

The paper provides a comprehensive gene expression profile of all 302 neurons in the C. elegans nervous system and identifies cis-regulatory elements and adhesion proteins involved in synaptic specificity.

The paper shows that bHLH transcription factors regulate lineage convergence in C. elegans neurons by controlling terminal selector gene expression.

The paper shows that DAF-16/FoxO and DAF-12/VDR control cellular plasticity both cell-autonomously and through interorgan signaling in C. elegans.

The paper introduces NeuroPAL, a multicolor transgene for neuronal identification in C. elegans, and demonstrates its use in mapping neurotransmitter receptors, cell fate changes, and brain activity.

The paper characterizes molecular and functional changes in post-mitotic neurons of C. elegans across development, identifying regulatory mechanisms and a gene involved in temporal behavioral transitions.

The paper re-evaluates the connectome of the C. elegans pharyngeal nervous system using serial EM reconstruction, revealing a more detailed structure and sensory-motor characteristics.

The paper compares the neuroanatomy and connectivity of the chemosensory system in two nematode species, finding conservation in neuronal number and position but divergence in ciliary morphology and synaptic wiring.

Transcriptomes of 52,412 neurons resolve 109 of the 118 canonical hermaphrodite neuron classes, and neuropeptide genes separate subtypes inside individual classes.

The paper examines how environmental stress induces plasticity in the electrical connectome of C. elegans by altering innexin expression in specific neuron types.

The paper identifies a regulatory pathway controlling the timing of sexual differentiation in C. elegans and shows its conservation in mice and humans.

This paper creates a molecular atlas of chemoreceptor expression in C. elegans, showing their diverse expression patterns across neuron types and revealing plasticity during developmental stages.

The paper identifies pals-22 as a gene required to prevent silencing of repetitive transgenes in C. elegans somatic tissues and links it to RNAi-dependent mechanisms.

The paper identifies dmd-3 as a conserved transcription factor controlling sex-specific differentiation of PHC neurons in C. elegans through cell-autonomous mechanisms.