Katharina Höfer

Harmonized nucleoside mass spectrometry enables reproducible cross-platform RNA modification quantification

The paper benchmarks cross-platform RNA modification quantification using LC-MS/MS and finds that harmonized workflows and SILIS normalization improve reproducibility across different instrument types.

DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity

Strain-level diversity of giant viruses infecting chlorarachniophyte algae in the subtropical North Pacific

The paper describes four isolates of a giant virus infecting chlorarachniophyte algae, highlighting strain-level genetic and epigenetic variation.

Proteins are a source of glycans found in preparations of glycoRNA

The paper shows that glycoproteins co-purify with RNA during glycoRNA isolation, suggesting they contribute glycans to glycoRNA preparations.

Engineering site-specific nucleic acid-protein conjugates by utilizing a natural RNAylation reaction

This paper establishes RNAylation as a method to create site-specific nucleic acid-protein conjugates with improved stability and delivery capabilities in human cells.

T4 phage RNA is NAD-capped and alters the NAD-cap epitranscriptome of Escherichia coli during infection

This study identifies NAD-capped RNAs during T4 phage infection of E. coli, showing dynamic changes in NAD-capping and revealing a phage-encoded Nudix hydrolase involved in NAD-RNA decapping.

Identification of NAD-RNAs and ADPR-RNA decapping in the archaeal model organisms Sulfolobus acidocaldarius and Haloferax volcanii

The paper identifies NAD-RNAs and ADPR-RNA decapping in archaea, showing NAD-RNAs are prevalent in Sulfolobus acidocaldarius and Haloferax volcanii, and Saci_NudT5 hydrolyzes ADPR-RNA.