The paper shows re-replication is a physiological mechanism in human stem cell differentiation, increasing gene copy numbers to meet protein demands during differentiation.

Cell Death Discovery · Jul 29, 2026Peer-reviewedGenomics

ABC-HuMi: the Atlas of Biosynthetic Gene Clusters in the Human Microbiome

Pascal Hirsch, Azat Tagirdzhanov, Aleksandra Kushnareva, Ilia Olkhovskii, Simon Graf, Georges Pierre Schmartz, Julian D. Hegemann, Kenan A. J. Bozhüyük, Rolf Müller, Andreas Keller, Alexey A. Gurevich

ABC-HuMi catalogs 19,218 biosynthetic gene clusters from the human microbiome, offering a comprehensive resource for exploring bioactive compound potential.

Nucleic Acids Research · Oct 30, 2023Peer-reviewedBioinformatics

Broad transcriptional dysregulation of brain and choroid plexus cell types with COVID-19

Andrew C. Yang, Fabian Kern, Patricia Morán Losada, Maayan R. Agam, Christina A. Maat, Georges Pierre Schmartz, Tobias Fehlmann, Julian A. Stein, Nicholas Schaum, Davis P. Lee, Kruti Calcuttawala, Ryan T. Vest, Daniela Berdnik, Nannan Lu, Oliver Hahn, , Tony Wyss‐Coray

The paper analyzes single-nucleus transcriptomes from brain and choroid plexus tissues of COVID-19 and influenza patients, identifying broad transcriptional dysregulation in multiple cell types and linking these changes to neurological symptoms.

Nature · Jun 21, 2021Peer-reviewedNeuroscience