Juraj Koudelka

Cerebral small vessel disease due to Col4a1 mutations include cognitive impairment and white matter defects that can be modulated by targeting protein folding.

This study identifies cognitive impairment and white matter defects in a mouse model of cerebral small vessel disease caused by Col4a1 mutations and shows that targeting protein folding can alleviate these issues.

Pulsation changes link to impaired glymphatic function in a mouse model of vascular cognitive impairment

This study shows that bilateral common carotid stenosis impairs glymphatic function and vascular pulsation in mice, contributing to cognitive decline in vascular cognitive impairment.