Author

Madison K. C. Seto

University of California, San FranciscoORCID 0000-0002-7900-5685Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Alex InagueiD· 1 shared Fangzhu ZhaoiD· 1 shared James A. OlzmanniD· 1 shared James A. WellsiD· 1 shared Kevin LeungiD· 1 shared Kun MiaoiD· 1 shared Snehal D. GanjaveiD· 1 shared Trenton M. Peters-ClarkeiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioengineering

Alex InagueORCID

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1 paper

Recent·Most cited

Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells

Fangzhu Zhao, Alex Inague, Trenton M. Peters-Clarke, Yifei Chen, Snehal D. Ganjave, Yun Zhang, Kun Miao, Zi Yao, Yan Wu, Madison K. C. Seto, Kevin Leung, James A. Olzmann, James A. Wells

This study shows that targeting LRP8 for degradation reduces GPX4 levels, sensitizing cancer cells to ferroptosis by disrupting selenium-dependent antioxidant defenses.

Proceedings of the National Academy of Sciences · Sep 30, 2026Peer-reviewedBioengineering