Author

John J. Y. Lee

University of CalgaryORCID 0000-0002-7967-3384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adam PtackiD· 1 shared Adriana PiteaiD· 1 shared Ahmed El Mouatani· 1 shared Alexander Gregory WeiliD· 1 shared Anna BäckströmiD· 1 shared Ashot S. HarutyunyaniD· 1 shared Audrey BaguetteiD· 1 shared Augusto Faria AndradeiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Adam PtackORCID

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2 papers

Recent·Most cited

H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs

Brian Krug, Bo Hu, Haifeng Chen, Claudia Negrón-Lomas, Xiao Chen, Ahmed El Mouatani, Kristjan H. Gretarsson, Adam Ptack, Shriya Deshmukh, Nisha Kabir, Wajih Jawhar, Augusto Faria Andrade, Elias Joseph Jabbour, Ashot S. Harutyunyan, Xinrui Wang, , Chao Lü

The paper shows that H3K27me3 spreading regulates chromatin architecture and gene repression, with implications for cell fate and tumor development.

Nature Genetics · May 18, 2026Peer-reviewedMolecular Biology

Mapping cell structure across scales by fusing protein images and interactions

Yue Qin, Edward L. Huttlin, Casper F. Winsnes, Maya L. Gosztyla, Ludivine Wacheul, Marcus R. Kelly, Steven M. Blue, Fan Zheng, Michael Chen, Leah V. Schaffer, Katherine Licon, Anna Bäckström, Laura Pontano Vaites, John J. Y. Lee, Wei Ouyang, , Trey E. Ideker

The paper integrates protein imaging and interaction data to create a unified map of eukaryotic cell structure, revealing new subcellular systems and protein associations.

Nature · Nov 24, 2021Peer-reviewedSystems Biology