This study evaluates a flow-conditioning anastomotic device to improve AVF hemodynamics and reduce endothelial injury by normalizing wall shear stress.

Bioengineering · Sep 19, 2026Peer-reviewedBioengineering

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney

Blue B. Lake, Ricardo Melo Ferreira, Jens Hansen, Rajasree Menon, Jeannine M. Basta, Heather Thiessen‐Philbrook, Stephanie Reinert, Robin Fallegger, Asmita Kishor Lagwankar, Xi Chen, Soumya Maity, Katerina V. Djambazova, Brittney L. Gorman, Nicholas Lucarelli, Debora L. Gisch, , Sanjay R. Jain

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

bioRxiv · Sep 26, 2025 · PreprintMolecular Biology

Microphysiological uremia model reveals biophysical potentiators of vascular dysfunction

Mitesh Rathod, Ryan N. Stack, Sarah E. Kubik, Stephanie A. Huang, Chloe P. Whitworth, Wen Yih Aw, Elizabeth L. Doherty, Sara M. Meehan, Prabir Roy‐Chaudhury, William J. Polacheck

This study uses a 3D microfluidic model to investigate how uremic toxins affect monocyte-endothelial interactions under hypertension and varying matrix stiffness.

Advanced Science · Jun 20, 2025Peer-reviewedBioengineering

Temporal evolution of hemodynamics in murine arteriovenous fistula: a micro-CT based computational fluid dynamics study

Lianxia Li, Unimunkh Uriyanghai, Christine Wai, Hong Yuan, Eric W. Livingston, Edward Moreira Bahnson, Vinay A. Sudarsanam, Samuel Haddad, Prabir Roy‐Chaudhury, Boyce E. Griffith, Gang Xi

This study uses micro-CT and CFD to analyze hemodynamic changes in murine AVF over time, identifying geometric and flow alterations linked to stenosis risk.

bioRxiv · Mar 24, 2025 · PreprintBioengineering