Linda M. Bradley

PSGL-1 blockade delays relapse to BRAF/MEK inhibition in cutaneous melanoma

This study shows that blocking PSGL-1 with BRAF/MEK inhibition improves durable tumor control in melanoma by reprogramming CD8+ T cells to a memory-like state.

CD155 regulates tumor growth and immune evasion in diffuse midline glioma.

This study identifies CD155 as a key regulator of tumor growth and immune evasion in diffuse midline glioma, showing that targeting CD155 or its downstream target FOXM1 can inhibit tumor progression.

Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer

This study shows that disabling PSGL-1 enhances anti-tumor immunity in pancreatic cancer by improving CD8+ T cell function and response to PD-1 blockade.

Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer

This study shows that macropinocytosis regulates CAF subtype identity under metabolic stress in PDAC, impacting tumor stroma and therapeutic response.