Jennifer L. Hope

PSGL-1 blockade delays relapse to BRAF/MEK inhibition in cutaneous melanoma

This study shows that blocking PSGL-1 with BRAF/MEK inhibition improves durable tumor control in melanoma by reprogramming CD8+ T cells to a memory-like state.

CD155 regulates tumor growth and immune evasion in diffuse midline glioma.

This study identifies CD155 as a key regulator of tumor growth and immune evasion in diffuse midline glioma, showing that targeting CD155 or its downstream target FOXM1 can inhibit tumor progression.

Disabling PSGL-1 abrogates immune suppression and resistance to PD-1 blockade in pancreatic cancer

This study shows that disabling PSGL-1 enhances anti-tumor immunity in pancreatic cancer by improving CD8+ T cell function and response to PD-1 blockade.

Population analysis and immunologic landscape of melanoma in people living with HIV indicate impaired antitumor immunity

This paper analyzes melanoma in people living with HIV, finding impaired antitumor immunity, delayed ICI treatment, and an immunosuppressive tumor microenvironment.

Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer

This study shows that macropinocytosis regulates CAF subtype identity under metabolic stress in PDAC, impacting tumor stroma and therapeutic response.