Author

Javier Aguilera‐Lizarraga

University of CambridgeORCID 0000-0002-8135-9933Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

David Colin BulmeriD· 2 shared Ewan St. John SmithiD· 2 shared Luke W PaineiD· 2 shared Anne RitouxiD· 1 shared Fraser WelshiD· 1 shared Gerhard RogleriD· 1 shared James P. HighamiD· 1 shared James R.F. HockleyiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

David Colin BulmerORCID

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2 papers

Recent·Most cited

GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception

Luke W Paine, Rohit Gupta, James P. Higham, Javier Aguilera‐Lizarraga, Anne Ritoux, Pritchard, Thomas, M.A., Samuel J. Nicholson, James R.F. Hockley, Tim Raine, Martin Hausmann, Kyle Bednar, Gerhard Rogler, Fraser Welsh, Ewan St John Smith, David Colin Bulmer

This study identifies GPR68 as a mediator of acid-induced colonic nociception through genetic and pharmacological approaches in mice.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2026Peer-reviewedNeuroscience

Pro-inflammatory mediators sensitise Transient Receptor Potential Melastatin 3 cation channel (TRPM3) signalling in mouse sensory neurons

Javier Aguilera‐Lizarraga, Tony K.Y. Lim, Luke A. Pattison, Luke W Paine, David Colin Bulmer, Ewan St. John Smith

This study investigates how inflammatory mediators affect TRPM3 channel function in mouse sensory neurons and finds that IL-1β and TNF potentiate TRPM3 without changing its expression, while pharmacological blockade does not alleviate inflammatory pain in a specific model.

bioRxiv · Sep 11, 2024 · PreprintNeuroscience