Matthew T. Swulius

In situ architecture of the endosymbiont Wolbachia pipientis

This study uses cryo-electron tomography to reveal the nanoscale architecture of Wolbachia pipientis structures involved in host manipulation and maternal inheritance.

Compromised 2-start zigzag chromatin folding in immature mouse retina cells driven by irregularly spaced nucleosomes with short DNA linkers.

The paper investigates chromatin structure in immature and mature mouse retina cells, finding that short DNA linkers disrupt the two-start zigzag folding, leading to less compact chromatin in immature cells.

Training Generalized Segmentation Networks with Real and Synthetic Cryo-ET data.

The paper trains segmentation networks for cryo-ET data using synthetic and real data, showing that synthetic data with molecular diversity improves performance but real data is needed for generalization.

Cryo-electron tomography reveals the multiplex anatomy of condensed native chromatin and its unfolding by histone citrullination

This study uses cryo-ET to reveal novel chromatin folding motifs in native human chromatin and shows how histone citrullination affects nucleosome stacking and self-association.