Author

Markéta Jiroušková

Czech Academy of SciencesORCID 0009-0004-7173-2177Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:multiome· 1

Frequent Co-Authors

Lenka Sarnová· 2 shared Martin GregoriD· 2 shared Afshan IqbaliD· 1 shared Anna Maria FrontinoiD· 1 shared Christoph H. MayriD· 1 shared Daniel V. OliveiraiD· 1 shared Elisabeth VerboveniD· 1 shared Emma Rachel AnderssoniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPathology

Lenka Sarnová

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2 papers

Recent·Most cited

Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis

Markéta Jiroušková, Karel Harant, Pavel Cejnar, Srikant Ojha, Katerina Korelova, Lenka Sarnová, Eva Sticová, Christoph H. Mayr, Herbert B. Schiller, Martin Gregor

The paper characterizes compartment-specific proteomic changes in liver fibrosis models and identifies potential therapeutic targets.

eLife · Apr 8, 2025Peer-reviewedPathology

Jag1 Insufficiency Disrupts Neonatal T Cell Differentiation and Impairs Hepatocyte Maturation, Leading to Altered Liver Fibrosis

Jan Mašek, Iva Filipovic, Noémi Van Hul, Lenka Belicová, Markéta Jiroušková, Daniel V. Oliveira, Anna Maria Frontino, Simona Hankeová, Jingyan He, Fabio Turetti, Afshan Iqbal, Igor Červenka, Lenka Sarnová, Elisabeth Verboven, Tomáš Brabec, , Emma Rachel Andersson

This study shows that Jag1 deficiency in a mouse model of Alagille syndrome leads to impaired liver fibrosis due to defective T cell differentiation and hepatocyte maturation.

bioRxiv · Oct 24, 2022 · PreprintDevelopmental Biology